Principal Investigator

David L Ollis Protein Structure, RSC, Australian National University

Project Title

Protein Refinement and Engineering

Brief Description for General Publications

Our research is focussed on the exciting interface between chemistry and biology. This area of research is crucial for understanding both the molecular basis of biological phenomena and for the utilisation of biological materials. Projects usually start with structure determination using diffraction techniques. Following this, structures are used to rationalise protein behaviour and to design experiments that further probe the intimate relationship between sequence, structure and function. Our current work has focussed on the following systems: 1) signal transduction: glutamine adenylyltransferase; 2) cell surface receptors: the b subunit of the Il5 receptor; and 3) replication protein: the e subunit of DNA polymerase III 4) Bio-remediation: the structures of enzymes that degrade organophosphates (opda,gpdq), 5) The trancription regulation protein, TyrR.